Indapamide
Indapamide (in DAP a mide) is a generic medication prescribed for high blood pressure, and salt and fluid buildup from heart failure. Indapamide belongs to a group of drugs called diuretics (water pills).
Indapamide (in DAP a mide) is a generic medication prescribed for high blood pressure, and salt and fluid buildup from heart failure. Indapamide belongs to a group of drugs called diuretics (water pills).
- Generic
- • Tablet
- • 2.5mg
- • 30 Tablets
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Intro
Introduction
Written by Julz Richterman, PharmD, MBA, BCGP
Medically reviewed by Amber Watson, PharmD
Updated on September 7, 2023
Indapamide (in DAP a mide) is a generic medication prescribed for high blood pressure, and salt and fluid buildup from heart failure. Indapamide belongs to a group of drugs called diuretics (water pills).
Side effects
Side effects of indapamide
Indapamide may cause mild or serious side effects. More common mild side effects of indapamide and its serious side effects are listed below. This article doesn’t include all possible side effects of the drug. Side effects can vary based on your age, overall health, and any other medications you take.
To learn more about indapamide’s side effects, ask your doctor or pharmacist. You can also refer to the prescribing information for indapamide listed in the “Resources” section.
Mild side effects
More common mild side effects reported with some forms of indapamide are listed below. These side effects may differ based on the strength of indapamide you take.
This article doesn’t include all possible mild side effects of the drug. To learn more about indapamide’s side effects refer to the prescribing information for indapamide listed in the “Resources” section.
With many drugs, mild side effects may go away within a few days or a couple of weeks. If the side effects are bothersome, tell your doctor or pharmacist. They may be able to suggest ways to manage them.
Indapamide’s mild side effects include:
- electrolyte imbalance, such as low potassium level and low sodium level
- headaches
- dizziness
- anxiety
- mild allergic reaction*
* For details about this side effect, see the “Interactions and warnings for indapamide” section.
Serious side effects
Serious side effects of indapamide are listed below. These side effects may differ based on the strength of indapamide you take.
This article doesn’t include all possible serious side effects of the drug. To learn more about indapamide’s side effects, refer to the prescribing information for indapamide listed in the “Resources” section.
With many drugs, serious side effects are possible but not common. If you have serious side effects from this drug, call your doctor right away. If you’re having severe symptoms or a medical emergency, call 911 or a local emergency number.
In general, indapamide’s serious side effects include:
- liver problems, such as hepatitis or jaundice (yellowing of the skin or whites of the eyes)
- inflamed (swollen) lungs or pancreas
- high uric acid level, which may lead to gout
- severe allergic reaction*
* For details about this side effect, see the “Interactions and warnings for indapamide” section.
FAQ
Common questions about indapamide
Below you’ll find answers to a few commonly asked questions about indapamide.
What brand names are available for indapamide?
In the U.S., the brand name for indapamide was Lozol, but it’s no longer made. There are several brand names available in other countries, but these are not available in the U.S. If you’re in the U.S. and your doctor prescribes Lozol, your pharmacy will automatically change it to indapamide, the generic version.
A generic medication is an identical copy of the active drug in a brand-name medication. An active drug is the ingredient that makes medication work. Generic drugs are believed to be as effective and safe as brand-name drugs. And generic drugs typically cost less compared to brand-name drugs.
Talk with your doctor or pharmacist to learn more about the differences between brand name and generic medications.
Is it safe to take indapamide with ramipril?
Indapamide and ramipril can be taken together if your doctor prescribes them. Both medications lower blood pressure, but in different ways.
Ramipril belongs to a group of drugs called angiotensin converting enzyme (ACE) inhibitors. ACE inhibitors lower your blood pressure by widening your veins and blood vessels. Indapamide belongs to a different group of drugs called diuretics (water pills).
If your doctor prescribes you a new blood pressure medication, they may decrease the dosage of your existing blood pressure medication. This is to help prevent your blood pressure from falling too low. Call your doctor immediately if you experience symptoms of low blood pressure. These include dizziness, lightheadedness, blurred vision, or fainting.
If you have questions about taking indapamide with ramipril, talk with your doctor or pharmacist. They can advise if you’ll need more monitoring while taking both drugs.
How does indapamide work? And how long does it take to start working?
Indapamide works in two different ways:
- It causes your kidneys to remove more water and salt through your urine. This decreases the amount of fluid in your body and blood. Fluid buildup due to heart failure* causes edema (swelling), often in your abdomen, legs, ankles, or feet. Getting rid of extra fluid can reduce swelling. Also, having less fluid in your blood lowers your blood pressure and makes it easier for your heart to pump blood through your body.
- It widens your veins and blood vessels. Tighter veins and blood vessels increase blood pressure* and make it more difficult for blood to get through. This means your heart must pump harder to move your blood. Widening your veins and blood vessels lowers blood pressure. It also makes it easier for your heart to move your blood through your body.
Indapamide starts working within a couple hours of taking it. But it may take 1–4 weeks for it to be fully effective.
If you’d like to know more about this, talk with your doctor or pharmacist.
* Indapamide is used to treat these conditions. For more details, see the “Uses of indapamide” section.
Interactions and warnings
Interactions and warnings for indapamide
Below, you’ll find information about indapamide’s possible interactions and warnings.
Interactions of indapamide
Certain things may affect how a drug works. These include getting vaccines, consuming alcohol or certain foods, or taking the drug with other medications. This effect is called a drug interaction.
Before you take indapamide, ask your doctor to check for possible interactions. Be sure to tell them about any of the following you take or use:
- prescription or over-the-counter drugs
- vitamins, herbs, or supplements
To learn about drug-condition interactions, see the “Warnings for indapamide” section below.
Warnings for indapamide
Some people should not take indapamide, and others should take it cautiously.
Indapamide could cause harm to people with certain health conditions. This effect is called a drug-condition interaction. Other factors can also affect whether indapamide is a safe option for you.
Ask your doctor about specific warnings for indapamide, and be sure to tell your doctor about your:
- current health, including any allergies to medications
- past health conditions or surgeries
Allergic reaction
Indapamide can cause an allergic reaction in some people. Severe allergic reactions are rare but possible.
If you’ve had an allergic reaction to indapamide or any of its ingredients, your doctor will likely not prescribe indapamide. They can tell you about medications that are safer options for you.
A mild allergic reaction may cause the following symptoms:
A severe allergic reaction may cause the following symptoms:
- swelling under your skin, usually in your hands, feet, eyelids, or lips
- swelling of your mouth, throat, or tongue, which can cause breathing problems
If you have an allergic reaction to indapamide, call your doctor right away. If you have severe symptoms, call 911 or a local emergency number.
Overdose of indapamide
If you take indapamide by mouth you should not take more indapamide than your doctor prescribes. For some drugs, doing so may lead to harmful effects or overdose.
If you think you’ve taken too much indapamide, call your doctor or pharmacist right away. Or you could call 800-222-1222 to speak with someone at America’s Poison Centers. You can also use its online resource. If you have concerning symptoms, call 911 or a local emergency number immediately. You can also go to the closest emergency room.
Pregnancy or breastfeeding and indapamide
Information about indapamide and pregnancy and breastfeeding is described below.
Indapamide and pregnancy
There are risks to taking indapamide during pregnancy. But there are also risks with having unmanaged high blood pressure or fluid buildup from heart failure while pregnant. (Keep in mind that indapamide is used for managing both conditions.)
If you’re planning a pregnancy or can become pregnant, talk with your doctor about your treatment options during pregnancy. Together, you can discuss the risks and benefits of your treatment options and decide whether or not you should take indapamide during pregnancy.
Indapamide and breastfeeding
It’s not known whether indapamide passes into breast milk. So it should not be taken while breastfeeding. If you’re currently breastfeeding or planning to do so, talk with your doctor before taking this medication. Your doctor may recommend other ways to feed your child during treatment with indapamide.
Uses
Uses of indapamide
The Food and Drug Administration (FDA) approves prescription drugs such as indapamide for certain conditions. Approved uses for indapamide are described below.
Use for high blood pressure
Doctors may prescribe indapamide oral tablet for treating high blood pressure, also known as hypertension. It’s used for this purpose in adults. It’s usually prescribed as a long-term treatment.
Blood pressure is how hard your blood pushes against the walls of your blood vessels. Your blood pressure consists of two numbers:
- Systolic blood pressure. Systolic blood pressure is the first and larger number of the two. This is the pressure in your blood vessels when your heart contracts (squeezes).
- Diastolic blood pressure. Diastolic blood pressure is the second and smaller number of the two. This is the pressure in your blood vessels when your heart relaxes between beats.
High blood pressure is when both numbers are routinely high. It doesn’t usually cause symptoms. But it can still cause damage to your heart and blood vessels. So be sure to take your medications as your doctor prescribes and follow up with them regularly.
Indapamide is prescribed by itself or together with other high blood pressure medications.
Use for salt and fluid buildup
Doctors may prescribe indapamide oral tablet for treating salt and fluid buildup from heart failure. It’s used for this purpose in adults. It’s usually prescribed as a long-term treatment.
With heart failure, your heart is weakened and cannot pump blood through your body as quickly as usual. Your kidneys can sense the smaller amount of blood going through them. So they’ll begin to hold onto more salt and water to increase the amount of fluid in your blood. This can help your heart beat harder, but it worsens your heart failure over time.
Symptoms of fluid buildup include:
- rapid weight gain (3 or more pounds in 1 day, or 5 or more pounds in 1 week)
- swelling of the abdomen, legs, ankles, or feet
- shortness of breath
- nausea
- feeling full when you haven’t eaten
Your doctor will likely prescribe indapamide with heart failure medications to help your heart beat stronger.
Ask your doctor
What to ask your doctor
Let your doctor know if you have questions about indapamide or would like more details about it.
Here’s a list of some possible questions you may want to ask your doctor:
- Will I need blood tests while I’m taking indapamide?
- Should I take indapamide at a certain time of day?
- Will my diabetes medications need to be adjusted while taking indapamide?
- Can I take indapamide if I am also taking lithium?
Resources
Resources
- Food and Drug Administration. (2023). Orange Book: Approved drug products with therapeutic equivalence evaluations. https://www.accessdata.fda.gov/scripts/cder/ob/index.cfm
- Goyal A, et al. (2023). ACE inhibitors. https://www.ncbi.nlm.nih.gov/books/NBK430896/
- Indapamide tablet. (2023). https://nctr-crs.fda.gov/fdalabel/services/spl/set-ids/0687ed93-4761-4f9c-887d-95309c03f60e/spl-doc
Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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