Schizoaffective disorder is a long-term illness in your brain. People with this illness have both the signs of schizophrenia and mood changes such as low mood or bipolar illness. With this illness, you may have trouble living with how you think, talk, and act. Your mood can change quickly from happy to sad. People with schizophrenia may have schizoaffective disorder too. This illness happens to the same amount of women and men of all races. There are two kinds of mood in schizoaffective disorder: Low mood or depression − You feel sad, empty, and have less pleasure in life. This happens more often to women and older people. Bipolar illness − Your mood and thinking may quickly change from happy to angry to sad. This is also called mania. Patients can have a raised mood, feel powerful, and feel they can do anything. This happens more often to younger people. People with schizoaffective disorder often do not want help. They may want to be left alone. If not treated, people with this brain illness may have many signs. When treated, people may get better.