Zofran, our superhero, is always facing villains that cause terrible injustices like nausea and vomiting. The villains chemotherapy, radiation therapy, and surgery are the biggest culprits. The therapeutic class for Zofran is anti-emetic.
How does Zofran work?
Zofran is a Serotonin (5-HT3) receptor antagonist. It will block the vomiting reflex by inhibiting 5-HT3 receptors in the vomiting center, the chemoreceptor trigger zone and in the small intestine.
Say what?
The medication works in the stomach to block the signals to the brain that cause nausea and vomiting.
That’s a good thing.
Who can take it?
It is usually prescribed for patients undergoing chemotherapy, radiation therapy, or serious surgery.
Doctors prescribe Zofran to patients over the age of four undergoing cancer treatment or surgery.
According to the Micromedex, studies have not been performed to establish safety and efficacy in children under four. Therefore, it is not recommended for children under four years old.
Zofran is available in the following dosage forms:
- Film
- Tablet, Disintegrating
- Tablet
- Solution
Side Effects
Zofran, like every other superhero, has its flaws. Fighting bad guys has an effect on innocent bystanders, no matter how hard Zofran tries to keep it within the battle zone.
Common side effects include:
- confusion
- dizziness
- fast heartbeat
- fever
- headache
- shortness of breath
- weakness
Less common side effects include:
- painful urination
- decrease in the frequency of urination
- decrease in urine volume
- difficulty with passing urine (dribbling)
For a more detailed list, check out the Micromedex at the U.S. National Library of Medicine.
