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Quetiapine oral tablet dosage: A detailed guide

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Form and strengthsDosageFAQHow it's takenCouponOverdoseAsk your doctorBoxed warnings
Doctors prescribe quetiapine oral tablet for certain mental health conditions. You take it by mouth one to three times per day.
Medically reviewed by Alex Brewer, PharmD, MBA
Updated on

This article describes quetiapine oral tablet’s dosages and strengths and gives details on how to take it. You’ll also find information on cost savings and coupon options for quetiapine. If you want to know more about quetiapine oral tablet, see this overview article. It covers details about the drug’s uses and side effects, ways to save on cost, and more.

Quetiapine oral tablet is a generic version of the brand-name drug Seroquel. Quetiapine also comes in an extended-release* oral tablet, but that form isn’t described in this article. To learn more about that form, talk with your doctor.

* “Extended release” means the drug is slowly released into your body over a long period of time.

Boxed warnings

This drug has boxed warnings about the risk of suicidal thoughts and behaviors, and increased risk of death in older adults with dementia-related psychosis. A boxed warning is the most serious warning from the Food and Drug Administration (FDA).

For details, see the end of this article.

Form and strengths of quetiapine

Quetiapine oral tablet comes as follows:

  • Form: oral tablet, which you’ll take by swallowing
  • Strengths: 25 milligrams (mg), 50 mg, 100 mg, 150 mg, 200 mg, 300 mg, and 400 mg

Dosage of quetiapine

This article describes the recommended dosages for quetiapine oral tablet. The drugmaker provides these dosages.

If your doctor prescribes this medication, you should follow the dosage they prescribe. Your doctor will determine the dosage that best meets your needs. Do not change your dosage of quetiapine oral tablet without your doctor’s recommendation.

Usual recommended dosages of quetiapine in adults

Usually, doctors start by prescribing a low dosage of quetiapine oral tablet. Then, they’ll adjust it over time until the right dosage is reached. Ultimately, your doctor will prescribe the smallest dosage of quetiapine oral tablet that gives the desired outcome.

Dosage for bipolar disorder and other conditions

The following table shows the recommended dosages of quetiapine oral tablet for adults in milligrams (mg).

ConditionStarting dosageRecommended dosageMaximum dosage
schizophrenia 25 mg twice per dayTwo options:
• for short-term treatment: 150–750 mg divided into 2 or 3 doses per day
• for long-term treatment: 400–800 mg divided into 2 or 3 doses per day
Two options:
• for short-term treatment: 750 mg divided into 2 or 3 doses per day
• for long-term treatment: 800 mg divided into 2 or 3 doses per day 
bipolar I disorder100 mg twice per day400–800 mg divided into 2 doses per day800 mg divided into 2 doses per day
mania related to bipolar I disorder100 mg twice per day400–800 mg divided into 2 doses per day800 mg divided into 2 doses per day
depression related to bipolar I or bipolar II disorder50 mg once per day at bedtime300 mg once per day at bedtime300 mg once per day at bedtime

Dosages of quetiapine in children

The following table shows the recommended dosages for children in milligrams (mg).

ConditionStarting dosageRecommended dosageMaximum dosage
schizophrenia in children ages 13 years and older25 mg twice per day400–800 mg divided into 2 or 3 doses per day800 mg divided into 2 or 3 doses per day 
mania related to bipolar I disorder in children ages 10 years and older25 mg twice per day400–600 mg divided into 2 or 3 doses per day600 mg divided into 2 or 3 doses per day

Dosage adjustments for quetiapine

Your doctor will prescribe a dosage of quetiapine oral tablet based on several factors. These include:

  • the specific condition being treated and how severe it is
  • your age
  • other health conditions you may have
  • other medications you may take

Missed dose of quetiapine

Talk with your doctor or pharmacist right away if you realize you forgot to take a dose of quetiapine oral tablet. They may advise you to take the missed dose. Or they may advise you to skip it and take your next dose as scheduled.

For tips on how to plan your doses of quetiapine oral tablet and avoid missing a dose, read this article. You could also try:

  • downloading a reminder app on your phone
  • setting an alarm
  • putting a note where you’ll see it, such as on your calendar, bathroom mirror, or bedside table

Frequently asked questions

Below are answers to some commonly asked questions about quetiapine oral tablet and its dosage.

Can quetiapine be prescribed for sleep or anxiety? If so, what is the dosage?

Possibly, but quetiapine oral tablet is not approved for these uses.

Quetiapine is approved to treat certain mental health conditions in adults and some children. These include:

However, doctors may prescribe quetiapine off-label for sleep or anxiety. With off-label use, doctors prescribe a drug for a purpose other than what it’s approved for.

If you have questions about taking quetiapine for sleep or anxiety, talk with your doctor. They can give you more information about the dosage for these uses.

What is considered a high dose of quetiapine?

It depends. What is considered a high dose of quetiapine oral tablet may vary from person to person. For example, this could refer to a dose at the higher end of a recommended range or one that exceeds the maximum dosage.

The maximum dosage of quetiapine varies from 300–800 milligrams (mg) per day depending on the condition that’s being treated. The starting dosage and recommended dosages of quetiapine also vary.

For more information on the recommended dosages of quetiapine, see the “Dosage of quetiapine” section above. You can also talk with your doctor or pharmacist.

Is quetiapine taken long term?

Yes, it’s taken long term for certain conditions.

Quetiapine oral tablet is usually recommended for short-term treatment of manic or depressive episodes of bipolar disorder. If the drug works well for this use, your doctor will likely recommend you continue taking the drug long term to treat bipolar I disorder.

Doctors typically prescribe quetiapine oral tablet as a long-term treatment for schizophrenia and bipolar I disorder. If you and your doctor determine that it’s safe and effective for either condition, you’ll likely take it long term.

If you have questions about how long you should take quetiapine oral tablet, talk with your doctor.

How quetiapine is taken

You’ll swallow quetiapine oral tablet one to three times per day, depending on the condition that’s being treated.

Your doctor may advise that you take this medication around the same time each day. This helps keep a consistent amount of the drug in your body. And that can help the drug work more effectively.

The drugmaker doesn’t specify whether you can split, crush, or chew quetiapine tablets. If it’s hard for you to swallow tablets, view this article. It provides suggestions on how to swallow medications that come in pill form.

Also, be sure to talk with your doctor or pharmacist if you’re having difficulty taking your medication. They can offer recommendations about taking it.

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Overdose of quetiapine

It’s important that you do not take more quetiapine oral tablet than your doctor prescribes. Doing so can lead to harmful effects.

Symptoms of quetiapine overdose

Symptoms of an overdose can include:

In extreme cases, overdose can lead to coma or be fatal.

What to do if you take too much quetiapine

If you think you’ve taken too much quetiapine, call your doctor or pharmacist right away. Or you could call 800-222-1222 to speak with someone at America’s Poison Centers. You can also use its online resource. If you have severe symptoms, call 911 or a local emergency number immediately. You can also go to the closest emergency room.

What to ask your doctor

This article describes the usual recommended dosages for quetiapine oral tablet. If your doctor prescribes this medication, they’ll determine the dosage that’s best for you.

Do not change your dosage of quetiapine oral tablet without your doctor’s recommendation. You should take quetiapine oral tablet exactly as your doctor prescribes it. Let your doctor know if you have concerns or questions about your treatment plan.

Here’s a list of some possible questions you may want to ask your doctor:

  • Will you adjust my dosage if I have bothersome side effects?
  • Will you change my dosage if the current dosage isn’t working for my condition?
  • Is my dosage affected by other medications I take?

Boxed warnings for quetiapine

This drug has boxed warnings about the following risks. A boxed warning is the most serious warning from the Food and Drug Administration (FDA).

Risk of suicidal thoughts and behaviors. Taking quetiapine oral tablet may increase the risk of suicidal thoughts and behaviors. This risk applies to any drug used to treat depression and affects children, adolescents, and young adults up to 24 years of age. But keep in mind that quetiapine isn’t approved for use in children younger than 10 years of age. And the drug is only approved to treat depression related to bipolar disorder in adults. It’s not used to treat any form of depression in people under age 18 years.

Doctors will watch for unusual behavior or mood changes during quetiapine treatment. Examples include thoughts of death or self-harm, new or worsened anxiety or depression, and aggressive behavior. If you have these symptoms, contact your doctor right away. They can tell you whether it’s safe to continue quetiapine treatment.

Increased risk of death in older adults with dementia-related psychosis. Taking quetiapine oral tablet may increase the risk of death in people ages 65 years and older with dementia-related psychosis.

Dementia is a condition that causes problems with thinking, memory, and communication. Psychosis is a group of symptoms that alters the sense of reality.

Due to this risk, quetiapine isn’t typically prescribed for older adults with dementia-related psychosis.

You can talk with your doctor to learn more.

Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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