There are many types of pain, and pain often affects overall well-being. Whether your pain is short and sudden, like a headache, or progressive and chronic, knowing what pain management methods work best for you can be helpful.
The type of pain relief most suitable for you may depend on whether your pain is chronic, what’s causing it, and how severe it is. OTC medication options can help with mild or temporary pain, whereas stronger pain relief medications are only available by prescription.
OTC medications

OTC pain-relieving medications are available to buy from pharmacies and drug stores without a prescription. There are two common types: nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen (Tylenol).
Acetaminophen
Acetaminophen (Tylenol) has many general uses, including helping reduce fever. It can also help manage minor aches and pain caused by:
- headaches
- the common cold
- backache
- menstrual cramps
- strains and sprains
- toothache
- arthritis
Acetaminophen (Tylenol) is available in multiple strengths, and you can use it alongside NSAIDs. To avoid liver damage, you should not use more than 4,000 milligrams (mg) of acetaminophen per day.
Acetaminophen typically has minimal side effects. However, some people may experience an upset stomach, nausea, or constipation.
NSAIDs
NSAIDs help treat pain as well as symptoms of fever and inflammation in the body.
These drugs help manage pain caused by conditions such as:
- headache
- arthritis
- menstrual cramping
- minor injuries like sprains
Some NSAIDs that are available to buy OTC include:
When taken as the label instructs, these medications are safe. However, as with any drug, there are risks and possible side effects, such as:
- diarrhea
- high blood pressure
- stomach bleed
- kidney injury
- heart attack
- stroke
If you need help covering the cost of medications, the free Optum Perks Discount Card could help you save up to 80% on prescription drugs. Follow the links on drug names for savings on that medication, or search for a specific drug here.
Prescription medications
The following types of medications are typically high strength and therefore only available by prescription.
Corticosteroids
Corticosteroids are a type of medication used to treat many different conditions, from seasonal allergies to arthritis. They work to relieve pain by reducing inflammation.
They can help manage pain from a range of health conditions, such as:
- arthritis
- eczema
- gout
- lupus
Common corticosteroids include:
- prednisolone (Orapred)
- cortisone (Cortone)
- dexamethosone (Decadron)
There are several side effects that can occur when taking oral steroid medications. These can include:
- high blood pressure
- diabetes
- glaucoma
- muscle atrophy
- behavioral change