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Medically Approved

Linzess dosage: A detailed guide

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Form and strengthsDosageFAQCouponOverdoseBoxed warning
Doctors prescribe Linzess for certain types of constipation in adults and some children. You take it by mouth once per day.
Medically reviewed by Audrey Amos, PharmD
Updated on

This article describes the dosages and strengths of Linzess and gives details on how to take it. You’ll also find information on cost savings and coupon options for Linzess. If you want to know more about Linzess, see this overview article. It covers details about the drug’s uses and side effects, ways to save on cost, and more.

Linzess is a brand-name medication that comes as a capsule that you swallow. It isn’t available in a generic version. This article describes dosages of Linzess.

Linzess has a boxed warning. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). For details, see the end of this article.

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Form and strengths of Linzess

Linzess comes as follows:

  • Form: oral capsule that you swallow
  • Strengths: 72 micrograms (mcg), 145 mcg, 290 mcg

Dosage of Linzess

This article describes the recommended dosages for Linzess. The drugmaker provides these dosages. In some cases, doctors may adjust your dosage from those shown below.

If your doctor prescribes this medication, you should follow the dosage they prescribe. Your doctor will determine the dosage that best meets your needs. Do not change your dosage of Linzess without your doctor’s recommendation.

Usual recommended dosages of Linzess in adults

You should take Linzess on an empty stomach at least 30 minutes before a meal. You should swallow the capsule whole and take it around the same time each day.

Dosage for certain types of constipation

ConditionRecommended doseFrequency
 irritable bowel syndrome with constipation (IBS-C) 290 mcgonce daily 
chronic idiopathic constipation (CIC)145 mcg*once daily

* For CIC, you can take a 72 mcg dosage of Linzess if you cannot tolerate a dose of 145 mcg per day.

Dosages of Linzess in children

Doctors can prescribe Linzess for children ages 6 to 17 years who have functional constipation. The usual recommended dosage is 72 mcg daily.

If your child has trouble swallowing capsules whole, you can open the capsule. Then add the Linzess beads to applesauce or mix them in water for your child to take. Putting Linzess beads in other soft foods or liquids has not been tested.

Frequently asked questions

Below are answers to some commonly asked questions about Linzess and its dosage.

Can Linzess be taken twice per day?

No. Linzess is only approved to be taken once daily. Taking it twice per day could increase your risk of side effects and overdose. See the “Overdose of Linzess” section below for more details about overdose.

Talk with your doctor if you have concerns about your current dosage of Linzess.

What should I do for a missed dose of Linzess?

If you realize you forgot to take a dose of Linzess, you should skip that dose. Take the next dose at your regularly scheduled time. You should not take two doses at the same time. Talk with your doctor if you have questions about a missed dose of Linzess.

For tips on how to plan your doses of Linzess and avoid missing a dose, read this article. You could also try:

  • downloading a reminder app on your phone
  • setting an alarm
  • putting a note where you’ll see it, such as on your calendar, bathroom mirror, or bedside table

Can Linzess be used for opioid-induced constipation? If so, what’s the dosage?

Linzess is not approved to be used for opioid-induced constipation. But your doctor may still prescribe it for this purpose. This is considered off-label use. With off-label use, doctors prescribe a drug for a purpose other than what it’s approved for.

Keep in mind that there are other approved drug therapies for opioid-induced constipation. Your doctor may want to try those before suggesting Linzess.

Talk with your doctor to learn more about the best treatment for you and your condition.

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Overdose of Linzess

It’s important that you do not take more Linzess than your doctor prescribes. Doing so can lead to harmful effects.

Symptoms of Linzess overdose

Symptoms of an overdose can include:

What to do if you take too much Linzess

If you think you’ve taken too much Linzess, call your doctor or pharmacist right away. Or you could call 800-222-1222 to speak with someone at America’s Poison Centers. You can also use its online resource. If you have severe symptoms, call 911 or a local emergency number immediately. You can also go to the closest emergency room.

Boxed warning for Linzess

Linzess has a boxed warning for the risk of serious dehydration in children less than 2 years old. A boxed warning is the most serious warning from the FDA.

Risk of serious dehydration in children less than 2 years old: Linzess can cause serious and life threatening dehydration in children less than 2 years old. This is when their body loses too much water. Symptoms can include excessive thirst, dizziness, fatigue, decreased urination, and rapid heart rate or rapid breathing.

Seek medical attention if your baby’s diaper is dry for more than 6 hours. Because of the risk of dehydration, Linzess should not be used in children under 2 years old.

Talk with your doctor to learn more.

Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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