Endometriosis can cause severe pain due to trapped tissue and lesions forming outside of the uterus and womb. Over-the-counter (OTC) medications such as ibuprofen and naproxen can get to work quickly and help relieve some pain symptoms.
However, advanced treatment options such as medications, surgery, and natural remedies are sometimes necessary to provide a more effective and long-term solution.
Speaking with a healthcare professional about your symptoms is important to determine which treatment options may work for you.
Birth control pills

Birth control pills can help ease endometriosis symptoms and are one of the most common forms of treatment for the condition. They work by lowering estrogen levels and preventing or shortening your menstrual cycle.
The medication is available in two forms: progestin-only pills — also known as the minipill — and combined contraceptive pills.
Combined contraceptive pills contain estrogen and progestin. They can help lessen pain associated with heavy and painful periods.
Examples of combined contraceptive pills include:
- Dasetta
- norethindrone (Camila)
- levonorgestrel (Aviane)
The minipill contains only progestin and can help to reduce heavy menstrual bleeding and pelvic pain.
Examples of progestin-only pills include norethindrone and desogestrel.
Taking birth control pills can cause side effects such as:
- breast tenderness
- nausea
- irregular bleeding, such as spotting between periods
- mood changes
It’s important to speak with a doctor or healthcare professional to determine if birth control pills are the best option for you in relieving endometriosis pain.
If you need help covering the cost of medications, Optum Perks’ free Discount Card could help you get up to 80% off prescription medication. See how much you can save on your medication here.
GnRH (gonadotropin-releasing hormone) agonists
GnRH agonists work by stopping estrogen production in your body and preventing ovulation and menstruation from occurring. They can even be effective in stopping further endometrial growth.
Recent studies have found that GnRH agonists can help ease severe pelvic pain and provide a symptom-free period for up to 12 months.
Examples of GnRH agonists include Lupron (leuprorelin) and Decapeptyl (triptorelin).
They are available in the following forms:
- nasal spray
- injection, commonly delivered into a muscle or the abdominal wall
- pills
It’s important to know that taking GnRH agonists can invoke temporary symptoms of menopause. Other common side effects include:
- bone thinning when used for more than 6 months
- vaginal dryness
- mood changes
- hot flashes and sweats
If you choose to stop taking GnRH agonists, your symptoms of endometriosis may return.
Surgery
Surgery can be an effective option in treating and gaining a positive diagnosis of endometriosis, as the condition can be difficult to spot without seeing the inside of the abdomen.
It’s important to speak with a healthcare professional or doctor about whether surgery is the best option for you, as some treatments can permanently affect your ability to conceive.
Laparoscopy
Laparoscopy is one of the most common surgeries offered to people with endometriosis. It’s a minimally invasive procedure that can allow a surgeon to see into your abdomen and provide a confirmed diagnosis of endometriosis.
The surgery involves a small incision into your abdomen to insert a camera. At this point, a surgeon will decide whether to proceed based on the number of lesions and scarring. If they choose to continue, they will remove excess tissue and any adhesions.
It can provide relief to those who have previously not found medication to be effective in treating endometriosis pain and can offer a long-term solution in minimizing most symptoms in up to 70% of people.
Risks involved with laparoscopy can include:
- uncontrolled bleeding
- blood clots in legs or lungs
- severe pain at the incision site
- nausea and vomiting
- fever
It’s important to remember that laparoscopy is not a cure for endometriosis, and it is possible for excess tissue to regrow after surgery.