Chronic fatigue or tiredness can have many causes, including sleep deprivation, nutrient deficiencies, or conditions like diabetes, hypothyroidism, or Lyme disease. Lifestyle changes and treating underlying health issues may help boost energy.
Medically reviewed by Avi Varma, MD, MPH, AAHIVS, FAAFP
Feeling tired is a natural response to physical or mental exertion, and it typically goes away after resting.
Chronic fatigue, on the other hand, is a constant feeling of tiredness and low energy that doesn’t go away even after rest or sleep. It can be frustrating and keep you from feeling your best daily.
Always feeling tired can be due to different factors, from diet to living with health conditions. Here are some of the most common reasons you may feel tired all the time.
Lack of sleep
Not getting enough quality sleep is a common reason you may feel tired.
Sleep deprivation, or not being able to sleep as many hours as your body needs, can result from living with the following:
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A 2020 narrative review explains that deficiencies in nutrients like iron, vitamin B12, vitamin C, zinc, and magnesium may make you feel persistently tired.
Iron deficiency is often related to anemia, which occurs due to low hemoglobin levels. Hemoglobin carries red blood cells around your body, and a low level is a common cause of long-term tiredness.
Depending on the nutrient and severity of the deficiency, other symptoms of deficiencies may include:
feeling weak
muscle aches and cramps
shortness of breath
headaches
nausea
appetite changes
memory loss or brain fog
Management strategies and treatments for nutrient deficiencies also depend on the type and severity of the deficiency. They may include:
iron supplements for anemia, like ferumoxytol (Feraheme)
Your heart pumps oxygen around your body, which helps keep you healthy and energized. There are many types of heart-related conditions, spanning from high blood pressure to acute cardiovascular emergencies.
As well as constantly feeling tired, heart disease may manifest with:
chest pain
shortness of breath
swelling in your legs and feet
dizziness
nausea
cough
Sometimes, you may feel tired but have no symptoms at all. Only a healthcare professional can give a correct diagnosis.
Management and treatment options for heart-related conditions may depend on the type and severity of the symptoms alongside your overall health and needs but may include:
the angiotensin-converting enzyme (ACE) inhibitor benazepril (Lotensin)
surgery, like placing a stent if medications aren’t enough to prevent or treat the disease
lifestyle changes, including a nutrient-dense diet and more exercise
weight loss if you have overweight or obesity
quitting smoking if you smoke
Lifestyle factors
Lifestyle factors beyond a lack of sleep may contribute to chronic tiredness and fatigue. For instance, eating a diet low in vitamins and minerals or not being as physically active.
Depending on the cause of your tiredness, management options to consider include:
Exercising regularly: A 2020 randomized controlled trial of 38 people with axial spondyloarthritis found that high intensity exercise and strength training significantly improved energy levels.
Following a healthy, balanced diet: A nutrient-dense diet can also improve fatigue. Eating whole grains, vegetables, and omega-3 fatty acids may improve energy.
Reducing or stopping smoking and drinking alcohol: A 2023 study found that smoking and drinking alcohol can increase tiredness. So, cutting down or stopping may improve chronic fatigue.
If you have tried to stop smoking without lasting success, specific over-the-counter remedies and prescription medications may help. You can discuss these options with a healthcare professional:
Arthritis is chronic inflammation in your joints. There are different types of arthritis, many of which may cause long-term fatigue — for example, rheumatoid arthritis.
Other symptoms of arthritis may include:
joint pain, stiffness, and swelling
rash and psoriasis
fever
sleep issues
Treatment depends on which type of arthritis you have. Some options may include:
physical therapy
weight loss if you have overweight or obesity
nonsteroidal anti-inflammatory drugs like ibuprofen (Advil)
Feeling tired or fatigued is a natural part of life, but it can be frustrating if it becomes continuous.
Potential underlying causes of constantly feeling tired may include nutrient deficiencies, conditions such as Lyme disease and diabetes, and lifestyle factors like smoking or a lack of sleep.
Treatment options are available, from increased exercise to specific medications for each cause.
The best place to start is to talk with a doctor, who can help identify any potential underlying causes and advise on how to address them to get your energy levels back in check.
Li H, et al. (2023). Exploring causal effects of smoking and alcohol related lifestyle factors on self-report tiredness: A Mendelian randomization study. https://pubmed.ncbi.nlm.nih.gov/37327227
Sveaas SH, et al. (2020). High-intensity exercise improves fatigue, sleep, and mood in patients with axial spondyloarthritis: Secondary analysis of a randomized controlled trial. https://pubmed.ncbi.nlm.nih.gov/32367124